Eddie Crabbe

  • Eddie Crabbe
  • Adjunct Professor, KGI
  • Qualification: PhD

About

Dr. Crabbe has over 12 years experience in aerobic and anaerobic fermentation process development for recombinant protein and bioenergy production, technology transfer, and manufacturing support. Currently, Eddie works at Allergan in Irvine, California as a Senior Scientist in Biologics Development Process Sciences. In this role, he leads the design, development, scale up, characterization, and transfer of fermentation and primary recovery processes for the production of biologics and enzymes. He provides technology transfer expertise to in-house and external development and commercial manufacturing partners as well as contributing to manufacturing sections for CMC regulatory filings.

Prior to joining Allergan, he worked as a Senior Scientist in Kam Biotechnology in Surrey, Canada where he developed a lab scale platform for microbial hydrogen production from biological waste streams, provided proof-of-concept for a two-step continuous bioethanol production process, and supported manufacturing of bio-based (fungal and bacterial) products for applications in wastewater treatment.

Dr. Crabbe received a PhD in Microbial Technology, Food Science and Technology from Kyushu University in Japan.

ALS 427A

Fermentation Principles - Module I

Fermentation as a part of the bioprocess industry makes use of the microbial, animal and plant cells, and components of cells such as enzymes to manufacture enormous range of commercial products from relatively cheaper material such as industrial alcohol and organic solvents to expensive specialty chemicals such as antibiotics, therapeutic proteins and vaccines. The advancement and development of the fermentation process have led to the manufacturing of recombinant DNA derived products such as insulin, human growth hormone and interferon.

The knowledge and skills required to turn these products into commercial reality requires working with various interdisciplinary scientists and engineers to develop the necessary platforms from genetic manipulation and cell line development to scaling up the process to a pilot scale bioreactor and eventually industrial scale operations.

This course will focus on both the fermentation processes and the principles of bioprocessing engineering through a series of lectures, presentations and case studies.